The Monarch has recorded a personal message regarding his experience with cancer, set to air as part of this year's annual cancer awareness drive, spearheaded by Cancer Research UK and Channel 4.
Official sources stated the King would discuss his "recovery journey" as a individual battling cancer, in a video message on Friday at 8pm UK time.
The message, taped inside Clarence House a fortnight ago, will highlight the critical nature of cancer screening checks to increase the likelihood more people detect the disease at an early stage.
This will be a infrequent public commentary on the health of the Sovereign, who has been in a course of therapy since his condition was announced in early last year. Analysts suggest improbable the King will disclose his type of cancer.
The Stand Up To Cancer campaign each year generates donations for clinical trials and therapies and prompts people to get health assessments to increase the chances of an prompt identification.
The King's candid approach about his illness, and managing the disease, has been aimed to promote education and to persuade more people to get tested - and this will be advanced with this unique direct participation.
Up until now the King's key philosophy to his cancer has been to keep working, maintaining a full diary despite his regular rounds of care, and he seems not to have desired to be overshadowed by his illness.
This year has seen the King, 77, undertaking several overseas trips, such as visits to Italy and Canada, and hosting the biggest number of inward state visits to the UK for almost 40 years, which included the German president last week.
This Friday's Stand Up to Cancer broadcast on Channel 4, hosted by presenters like several TV personalities, will urge people not to be afraid of getting health screenings.
The hosts have been had experience with cancer - one host disclosed in November she had received treatment for breast cancer, while Clare Balding was treated for thyroid cancer over a decade ago. Presenter Adam Hills has previously mentioned his late father, who had a diagnosis and then later blood cancer.
The show will reach out to the estimated nine million people in the UK who health organisations estimate are not up to date with national health programmes, with an digital tool to let people see if they are eligible for tests for breast, bowel and cervical cancer.
In an effort to demystify health tests and illustrate the importance of early diagnosis there will be a real-time transmission from treatment centres at two Cambridge hospitals in Cambridge.
"I want to reduce the stigma out of health checks and prove everyone that they are not isolated in this," said a presenter.
Currently in the UK, there are several key NHS cancer screening programmes - for specific cancers - offered to certain age groups.
A recently launched lung cancer screening programme is also being slowly rolled out for individuals at increased risk of developing the illness, primarily aimed at people aged 55-74 years old, who currently smoke or have smoked in the past.
Men may discuss specific tests, but there is lacking a standardised service operational.
The Stand Up to Cancer initiative, which has collected over one hundred million pounds for many years, is funding dozens of medical projects encompassing thousands of patients.
His Majesty, in a statement for attendees at a reception for support groups in the spring, had referred to recognising the "daunting and at times alarming experience" for cancer sufferers and their loved ones.
But he noted his personal journey of managing cancer had demonstrated that "periods of great challenge of disease can be alleviated by the support of carers," as he commended those who supported those receiving treatment.
Royal representatives has not revealed the specific type of cancer the King has, or the therapies he has received. The King's cancer was identified subsequent to he had undergone a prostate procedure.
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